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Article

Tau assembly: the dominant role of PHF6 (VQIVYK) in microtubule binding region repeat R3.

The journal of physical chemistry. B - 2 Apr 2015

Ganguly Pritam, Do Thanh D, Larini Luca, LaPointe Nichole E, Sercel Alexander J, Shade Madeleine F, Feinstein Stuart C, Bowers Michael T, Shea Joan-Emma

Abstract excerpt

Self-aggregation of the microtubule-binding protein Tau reduces its functionality and is tightly associated with Tau-related diseases, termed tauopathies. Tau aggregation is also strongly associated with two nucleating six-residue segments, namely PHF6 (VQIVYK) and PHF6* (VQIINK). In this paper, using experiments and computational modeling, we study the self-assembly of individual and binary mixtures of Tau...

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Identifiers

PMID: 25775228
DOI: 10.1021/acs.jpcb.5b00175
PMCID: PMC4428543

Genes

PHF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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