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Article

OLFM4 modulates intestinal inflammation by promoting IL-22+ILC3 in the gut

29 Jul 2024

Abstract excerpt

Group 3 innate lymphoid cells (ILC3s) play key roles in intestinal inflammation. Olfactomedin 4 (OLFM4) is highly expressed in the colon and has a potential role in dextran sodium sulfate-induced colitis. However, the detailed mechanisms underlying the effects of OLFM4 on ILC3-mediated colitis remain unclear. In this study, we identify OLFM4 as a positive regulator of IL-22+ILC3. OLFM4 expression in colonic ILC3s...

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PMID: 39075283
DOI: 10.1038/s42003-024-06601-y

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