Article

A Gut-Specific Bispecific Combining MAdCAM-1 Blockade and IL-22 Signaling to Halt T-Cell Inflammation and Promote Mucosal Restoration

2026-08-10

Abstract excerpt

Inflammatory bowel disease (IBD) is a heterogeneous chronic disease driven by dysregulated mucosal immunity and impaired epithelial barrier function. Although biologics have improved disease management, they are frequently associated with systemic immunosuppression and adverse effects, highlighting the need for localized therapeutic strategies that both control inflammation and promote tissue repair. Here, we deve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d557c7a0-1d95-58cc-b915-cb860041b81b
DOI: 10.64898/2026.08.07.26359969

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Gut-Specific Bispecific Combining MAdCAM-1 Blockade and IL-22 Signaling to Halt T-Cell Inflammation and Promote Mucosal RestorationDOI 10.64898/2026.08.07.26359969Read

DNAM-1 immunoreceptor integrates innate and adaptive immune programs to drive intestinal inflammationSemantic proximity Read

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitisSemantic proximity Read

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protectionSemantic proximity Read

OLFM4 modulates intestinal inflammation by promoting IL-22+ILC3 in the gutSemantic proximity Read

CCR6-CCL20 Signalling Networks in Inflammatory Bowel DiseaseSemantic proximity Read

A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicitySemantic proximity Read

Modulatory Effects of IFN-γ and IL-22 on Inflammatory Signaling and Cellular Responses in Intestinal Epithelial CellsSemantic proximity Read

Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responsesSemantic proximity Read

IL-6 is a Key Factor in the Formation of Gut Tissue Resident Memory T Cells from Naïve T cellsSemantic proximity Read

CCR6-CCL20 Axis in IBD: What have we learnt in the past 20 years?Semantic proximity Read

Dual Immune Checkpoint and Cytokine Receptor Modulation by an Engineered Human CTLA-4/IL-10 Bispecific Fusion ProteinSemantic proximity Read

Suppression of epithelial proliferation and tumourigenesis by immunoglobulin ASemantic proximity Read