Article
Length-independent telomere damage drives cardiomyocyte senescence
2018-08-17
Abstract excerpt
Ageing is the biggest risk factor for cardiovascular health and is associated with increased incidence of cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated in age-related tissue dysfunction. Here, we address the question of how senescence is induced in rarely dividing/post-mitotic cardiomyocytes and investigate if clearance of senescent cells attenuat...
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Identifiers and source
- Literature Corpus work
- 520fde1c-4c9c-5dc3-9af7-4229680e46e7
- DOI
- 10.1101/394809