nuTCRacker: Predicting the Recognition of HLA‐I–Peptide Complexes by αβTCRs for Unseen Peptides

Abstract excerpt

T-cell clone can recognise would represent a quantum leap in the understanding of T-cell repertoire selection and development of targeted cell-mediated immunotherapies. Current methods fail to make accurate predictions for antigenic peptides not present in the training dataset. Here, we propose a novel deep learning method called nuTCRacker that makes accurate predictions for a subset of unseen peptides, with an...

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