Article

Identification of tumor-specific MHC ligands through improved biochemical isolation and incorporation of machine learning

2023-06-10

Abstract excerpt

Isolation of MHC ligands and subsequent analysis by mass spectrometry is considered the gold standard for defining targets for TCR-T immunotherapies. However, as many targets of high tumor-specificity are only presented at low abundance on the cell surface of tumor cells, the efficient isolation of these peptides is crucial for their successful detection. Here, we demonstrate how different isolation strategies, wh...

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Literature Corpus work: 73806f81-b117-51e7-861c-5a0eee98eb43
DOI: 10.1101/2023.06.08.544182

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