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Article

Combinatorial CAR design improves target restriction

2020-10-12

Abstract excerpt

CAR T cells targeting the B-lymphocyte antigen CD19 have led to remarkable clinical results in B-cell leukemia and lymphoma, but eliminate all B-lineage cells, leading to increased susceptibility to severe infections. As malignant B cells will express either immunoglobulin (Ig) light chain κ or λ, we designed a second-generation CAR targeting Igκ, IGK CAR. This construct demonstrated high target specificity, but d...

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Identifiers and source

Literature Corpus work
82325cc9-faf4-5ed2-ad2f-5b4ec29ee01a
DOI
10.1101/2020.10.09.333724
Open publication

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Combinatorial CAR design improves target restrictionDOI 10.1101/2020.10.09.333724
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