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Refining chimeric antigen receptors via barcoded protein domain combination pooled screening

12 Sept 2023

Abstract excerpt

Chimeric antigen receptor (CAR)-T cells represent a promising frontier in cancer immunotherapy. However, the current process for developing new CAR constructs is time consuming and inefficient. To address this challenge and expedite the evaluation and comparison of full-length CAR designs, we have devised a novel cloning strategy. This strategy involves the sequential assembly of individual CAR domains using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37705245
DOI: 10.1016/j.ymthe.2023.09.008

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