Article

Aberrant cytoplasmic localization of MLH1 characterizes a sub-clonal breast cancer cell population that seeds recurrence

2024-03-02

Abstract excerpt

Estrogen receptor positive (ER+) breast cancer is one of the most common causes of cancer-related death in women. Mortality is largely driven by recurrence of treatment-resistant disease after many years of apparent response, making the molecular events that cause recurrence a critical area of investigation. Loss of expression of MLH1 , a tumor suppressor best studied in its role in mismatch repair, induces resis...

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Literature Corpus work: 82245af5-0ced-58e2-ba6d-9d75e018a500
DOI: 10.1101/2024.02.27.582389

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