Article

Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer

2020-06-08

Abstract excerpt

Estrogen receptor positive (ER + ) breast cancer is a leading cause of cancer-related death globally. Resistance to standard of care endocrine treatment occurs in at least 30% of ER + breast cancer patients resulting in ~40,000 deaths every year in the US alone. Preclinical studies strongly implicate activation of growth factor receptor, HER2 in endocrine treatment resistance of ER + breast cancer that is HER2...

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Literature Corpus work: 26185e36-cbee-552f-b171-50d814947fd5
DOI: 10.1101/2020.06.08.128090

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