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Article

Truncation of the C-terminus of human MLH1 blocks intracellular stabilization of PMS2 and disrupts DNA mismatch repair.

DNA repair - 7 Mar 2006

Mohd Azizah B, Palama Brett, Nelson Scott E, Tomer Guy, Nguyen Megan, Huo Xin, Buermeyer Andrew B

Abstract excerpt

The human DNA mismatch repair (MMR) protein MLH1 has essential roles in the correction of replication errors and the activation of cell cycle checkpoints and cytotoxic responses to DNA damage that contribute to suppression of cancer risk. MLH1 functions as a heterodimer with the PMS2 protein, and steady state levels of PMS2 are very low in MLH1-deficient cells. Unique to MLH1 among MutL-homolog proteins, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16338176
DOI: 10.1016/j.dnarep.2005.11.001

Genes

MLH1
PMS2
CTH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Truncation of the C-terminus of human MLH1 blocks intracellular stabilization of PMS2 and disrupts DNA mismatch repair.PMID 16338176Read ↗

Truncation of the MSH2 C-terminal 60 amino acids disrupts effective DNA mismatch repair and is causative for Lynch syndrome.Semantic proximity Read ↗

Disentangling the mutational effects on protein stability and interaction of human MLH1Semantic proximity Read ↗

The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts.Semantic proximity Read ↗

Disentangling the mutational effects on protein stability and interaction of human MLH1Semantic proximity Read ↗

Disruption of protein-protein interaction hotspots in the C-terminal domain of MLH1 confers mismatch repair deficiency.Semantic proximity Read ↗

Identification of Lynch syndrome mutations in the MLH1-PMS2 interface that disturb dimerization and mismatch repair.Semantic proximity Read ↗

Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo.Semantic proximity Read ↗

Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.Semantic proximity Read ↗

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndromeSemantic proximity Read ↗

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndromeSemantic proximity Read ↗

The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complex.Semantic proximity Read ↗

Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2.Semantic proximity Read ↗

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