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Article

Correlation of MLH1 polymorphisms, survival statistics, in silico assessment and gene downregulation with clinical outcomes among breast cancer cases.

Molecular biology reports - 1 Jan 2020

Malik Saima Shakil, Zia Ayisha, Mubarik Sumaira, Masood Nosheen, Rashid Sajid, Sherrard Alice, Khan Muhammad Bilal, Khadim Muhammad Tahir

Abstract excerpt

This study aimed to investigate the role of MLH1 polymorphisms, respective protein structure prediction, survival analysis, related clinicopathological details and MLH1 expression in breast cancer (BC). Genotyping of selected SNPs in BC patients (493) and age matched controls (387) were performed by Tetra-ARMS PCR. Gene expression among breast tumors (127) and adjacent control tissues were analysed using reverse...

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PMID: 31701475
DOI: 10.1007/s11033-019-05175-x

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