Article
Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch.
Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2012
Haughian James M, Pinto Mauricio P, Harrell J Chuck, Bliesner Brian S, Joensuu Kristiina M, Dye Wendy W, Sartorius Carol A, Tan Aik Choon, Heikkilä Päivi, Perou Charles M, Horwitz Kathryn B
Abstract excerpt
Luminal breast cancers express estrogen (ER) and/or progesterone (PR) receptors and respond to hormone therapies. Basal-like "triple negative" cancers lack steroid receptors but are cytokeratin (CK) 5-positive and require chemotherapy. Here we show that more than half of primary ER(+)PR(+) breast cancers contain an ER(-)PR(-)CK5(+) "luminobasal" subpopulation exceeding 1% of cells. Starting from ER(+)PR(+)...
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