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Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets

2 Dec 2023

Abstract excerpt

Intratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity in clonal populations of cell models for estrogen receptor positive breast cancer. To this end, we established barcoded models of luminal breast cancer and rendered them resistant to commonly applied first line endocrine therapies. By isolating single clones from...

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PMID: 38042915
DOI: 10.1038/s41523-023-00604-4

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