Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tall cell carcinoma with reversed polarity of the breast harbouring IDH1 hotspot mutation: morphologic, immunohistochemical and genetic characterization of two cases.

Histopathology - 1 May 2026

Krings Gregor, Hashem Sherin, Apushkin Marsha A, Ang-Rabanes Tina L, Hoda Raza S

Abstract excerpt

AIMS: Tall cell carcinomas with reversed polarity (TCCRPs) are rare, indolent triple negative or oestrogen receptor (ER)-low positive breast cancers classically characterized by solid-papillary and papillary proliferations of eosinophilic columnar cells with reversed nuclear polarity. IDH2 R172 mutations are key oncogenic drivers in the majority of TCCRPs, exemplary of genotype-phenotype correlation among breast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to IDH2 gene

Share to PIK3CA gene

Share to Immunohistochemistry

Share to Isocitrate Dehydrogenase

Share to Mutation

Source

Identifiers

PMID: 41456872
DOI: 10.1111/his.70083

Genes

IDH1
IDH2
PIK3CA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tall cell carcinoma with reversed polarity of the breast harbouring IDH1 hotspot mutation: morphologic, immunohistochemical and genetic characterization of two cases.PMID 41456872Read ↗

Tall Cell Carcinoma with Reversed Polarity of the breast: Clinicopathological insights, molecular profile, and future therapeutic directionsSemantic proximity Read ↗

Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features.Semantic proximity Read ↗

The Diagnostic Utility of IDH2 R172 Immunohistochemistry in Tall Cell Carcinoma With Reversed Polarity of the Breast.Semantic proximity Read ↗

Tall cell carcinoma of the breast with reversed polarity (TCCRP) with mutations in the IDH2 and PIK3CA genes: a case report.Semantic proximity Read ↗

Immunohistochemical analysis of IDH2 R172 hotspot mutations in breast papillary neoplasms: applications in the diagnosis of tall cell carcinoma with reverse polarity.Semantic proximity Read ↗

Tall cell carcinoma of the breast with reverse polarity: case report with gene sequencing and literature reviewSemantic proximity Read ↗

Tall cell carcinoma with reversed polarity: case report with gene sequencing and literature reviewSemantic proximity Read ↗

Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (solid papillary carcinomas with reverse polarity) harbour recurrent mutations affecting IDH2 and PIK3CA: a validation cohort.Semantic proximity Read ↗

Solid papillary carcinoma with reverse polarity of the breast harbors specific morphologic, immunohistochemical and molecular profile in comparison with other benign or malignant papillary lesions of the breast: a comparative study of 9 additional cases.Semantic proximity Read ↗

Breast Tumor Resembling Tall Cell Variant of Papillary Thyroid Carcinoma: A Solid Papillary Neoplasm With Characteristic Immunohistochemical Profile and Few Recurrent Mutations.Semantic proximity Read ↗

Genotype-Phenotype Correlations in Breast Cancer.Semantic proximity Read ↗

Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.