Article

Mechanistic dissection of the <i>CHD4</i> enhancers reveals cooperative functions among the homotypic ZNF410 clustered motifs

2024-02-25

Abstract excerpt

<h4>SUMMARY</h4> Transcription factors often regulate numerous target genes. However, ZNF410 controls only a single gene, CHD4, in human erythroid cells by its highly restricted chromatin occupancy to the CHD4 locus via two clusters of ZNF410 binding motifs. Here, we uncover that ZNF410 controls chromatin accessibility and activity of the two CHD4 enhancer regions. Combining CRISPR/Cas9 genomic deletion with C...

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Literature Corpus work: 821fc293-16d0-5ae8-984d-f9b0d8578d8c
DOI: 10.1101/2024.02.24.581901

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