Article

ZNF410 represses fetal globin by devoted control of CHD4/NuRD

2020-08-31

Abstract excerpt

Major effectors of adult-stage fetal globin silencing include the transcription factors (TFs) BCL11A and ZBTB7A/LRF and the NuRD chromatin complex, although each has potential on-target liabilities for rational β -hemoglobinopathy therapeutic inhibition. Here through CRISPR screening we discover ZNF410 to be a novel fetal hemoglobin (HbF) repressing TF. ZNF410 does not bind directly to the γ -globin genes but ra...

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Literature Corpus work: d0a15b75-4012-50cc-baf0-778ea2eb4f81
DOI: 10.1101/2020.08.31.272856

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