Article

ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expression

2020-08-31

Abstract excerpt

<h4>Summary</h4> Metazoan transcription factors typically regulate large numbers of genes. Here we identify via a CRISPR-Cas9 genetic screen ZNF410, a pentadactyl DNA binding protein that in human erythroid cells directly and measurably activates only one gene, the NuRD component CHD4. Specificity is conveyed by two highly evolutionarily conserved clusters of ZNF410 binding sites near the CHD4 gene with no counte...

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Literature Corpus work: 03b3920a-c599-57c2-bd0f-3ffe825612c4
DOI: 10.1101/2020.08.31.274324

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