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Article

Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai

20 Jan 2025

Abstract excerpt

Abstract Hakai protein (CBLL1 gene) was identified as an E3 ubiquitin ligase of E-cadherin complex, inducing its ubiquitination and degradation, thus inducing epithelial-to-mesenchymal transition. Most of the knowledge about the protein was associated to its E3 ubiquitin ligase canonical role. However, important recent published research has highlighted the noncanonical role of Hakai, independent of its E3...

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PMID: 39833727
DOI: 10.1186/s11658-025-00693-y

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