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SHARPIN is a novel gene of colorectal cancer that promotes tumor growth potentially via inhibition of p53 expression

21 Oct 2024

Abstract excerpt

Colorectal cancer (CRC) is widely prevalent and represents a significant contributor to global cancer‑related mortality. There remains a pressing demand for advancements in CRC treatment modalities. The E3 ubiquitin ligase is a critical enzyme involved in modulating protein expression levels via posttranslational ubiquitin‑mediated proteolysis, and it is reportedly involved in the progression of various cancers,...

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PMID: 39450547
DOI: 10.3892/ijo.2024.5701

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