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Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer

18 Sept 2017

Abstract excerpt

Accumulative studies revealed that E3 ubiquitin ligases have important roles in colorectal carcinogenesis. The pathogenic mechanisms of colorectal cancer (CRC) initiation and progression are complex and heterogeneous, involving somatic mutations, abnormal gene fusion, deletion or amplification and epigenetic alteration, which may cause aberrant expression or altered function of E3 ligases in CRC. Defects of E3...

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PMID: 28925398
DOI: 10.1038/onc.2017.313

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