Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination

22 Jun 2022

Abstract excerpt

Ariadne homolog 2 (ARIH2) is a key member of the RING-between-RING (RBR) E3 ligase family, which is characterized by an RBR domain involved in the polyubiquitination process. However, the molecular mechanism and biological function of ARIH2 in the pathogenesis of gastric cancer remain unclear. In this paper, we found that high ARIH2 expression is correlated with poor prognosis in gastric cancer patients and that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to RNA modifications and cancer
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35732617
DOI: 10.1038/s41419-022-04965-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitinationPMID 35732617Read ↗

PJA2 suppresses colorectal cancer progression by controlling HDAC2 degradation and stability.Semantic proximity Read ↗

Pirh2Semantic proximity Read ↗

Functional roles of E3 ubiquitin ligases in gastric cancer (Review)Semantic proximity Read ↗

The Role of E3 Ligase Pirh2 in DiseaseSemantic proximity Read ↗

Pirh2 RING‐finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapySemantic proximity Read ↗

Ubiquitin-conjugating enzyme UbcH10 promotes gastric cancer growth and is a potential biomarker for gastric cancerSemantic proximity Read ↗

The Role and Clinical Implications of the Retinoblastoma (RB)-E2F Pathway in Gastric CancerSemantic proximity Read ↗

High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancersSemantic proximity Read ↗

Advancements and perspectives of RBX2 as a molecular hallmark in cancerSemantic proximity Read ↗

By recruiting HDAC1, MORC2 suppresses p21Waf1/Cip1 in gastric cancerSemantic proximity Read ↗

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation.Semantic proximity Read ↗

ICAM2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated RDX degradation to inhibit gastric cancer tumorigenicity and metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.