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The Role of HECT E3 Ubiquitin Ligases in Colorectal Cancer

7 Feb 2023

Abstract excerpt

Colorectal cancer (CRC) is estimated to rank as the second reason for cancer-related deaths, and the prognosis of CRC patients remains unsatisfactory. Numerous studies on gastrointestinal cell biology have shown that the E3 ligase-mediated ubiquitination exerts key functions in the pathogenesis of CRC. The homologous to E6-associated protein C-terminus (HECT) family E3 ligases are a major group of E3 enzymes,...

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PMID: 36831013
DOI: 10.3390/biomedicines11020478

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