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S100a4 promotes metastatic transformation in non-metastatic liver cancer cells through NMIIa binding: mechanistic insights

4 Jul 2025

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, characterized by high recurrence and metastasis rates. Studies have demonstrated that exosomes, as signaling mediators between tumor cells and their microenvironment, play crucial roles in tumor cell migration and invasion. S100A4, a known metastasis-associated protein, has been identified as a key factor in promoting cancer...

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PMID: 40616024
DOI: 10.1186/s12885-025-14502-4

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