Article
The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.
Traffic (Copenhagen, Denmark) - 1 Jun 2007
Nassoury Nasha, Blasiole Daniel A, Tebon Oler Angie, Benjannet Suzanne, Hamelin Josée, Poupon Vivianne, McPherson Peter S, Attie Alan D, Prat Annik, Seidah Nabil G
Abstract excerpt
Mutations in the proprotein convertase PCSK9 gene are associated with autosomal dominant familial hyper- or hypocholesterolemia. These phenotypes are caused by a gain or loss of function of proprotein convertase subtilisin kexin 9 (PCSK9) to elicit the degradation of the low-density lipoprotein receptor (LDLR) protein. Herein, we asked whether the subcellular localization of wild-type PCSK9 or mutants of PCSK9...
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