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Article

Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall.

Journal of cellular physiology - 1 Apr 2021

Guo Yanan, Yan Binjie, Gui Yu, Tang Zhihan, Tai Shi, Zhou Shenghua, Zheng Xi-Long

Abstract excerpt

Proprotein convertase subtilisin/kexin type-9 (PCSK9), a member of the proprotein convertase family, is an important drug target because of its crucial role in lipid metabolism. Emerging evidence suggests a direct role of localized PCSK9 in the pathogenesis of vascular diseases. With this in our consideration, we reviewed PCSK9 physiology with respect to recent development and major studies (clinical and...

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Identifiers

PMID: 32875580
DOI: 10.1002/jcp.30025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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