Article
Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding.
Nature communications - 2 Nov 2017
Toyoda Yusuke, Cattin Cedric J, Stewart Martin P, Poser Ina, Theis Mirko, Kurzchalia Teymuras V, Buchholz Frank, Hyman Anthony A, Müller Daniel J
Abstract excerpt
To divide, most animal cells drastically change shape and round up against extracellular confinement. Mitotic cells facilitate this process by generating intracellular pressure, which the contractile actomyosin cortex directs into shape. Here, we introduce a genome-scale microcantilever- and RNAi-based approach to phenotype the contribution of > 1000 genes to the rounding of single mitotic cells against...
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