Article
In vivo mitotic spindle scaling can be modulated by changing the levels of a single protein: the microtubule polymerase XMAP215.
Molecular biology of the cell - 1 Jun 2018
Milunovic-Jevtic Ana, Jevtic Predrag, Levy Daniel L, Gatlin J C
Abstract excerpt
In many organisms, early embryonic development is characterized by a series of reductive cell divisions that result in rapid increases in cell number and concomitant decreases in cell size. Intracellular organelles, such as the nucleus and mitotic spindle, also become progressively smaller during this developmental window, but the molecular and mechanistic underpinnings of these scaling relationships are not...
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