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Article

Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance.

Chembiochem : a European journal of chemical biology - 10 Dec 2010

Klüter Sabine, Simard Jeffrey R, Rode Haridas B, Grütter Christian, Pawar Vijaykumar, Raaijmakers Hans C A, Barf Tjeerd A, Rabiller Matthias, van Otterlo Willem A L, Rauh Daniel

Abstract excerpt

Targeting protein kinases in cancer therapy with irreversible small-molecule inhibitors is moving to the forefront of kinase-inhibitor research and is thought to be an effective means of overcoming mutation-associated drug resistance in epidermal growth factor receptor kinase (EGFR). We generated a detection technique that allows direct measurements of covalent bond formation without relying on kinase activity,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21080395
DOI: 10.1002/cbic.201000352

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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