Article

Tunable nucleofugality in carbamoyl-bearing covalent cholinesterase inhibitors

2025-08-25

Abstract excerpt

A handful of carbamate warheads is utilised in chemical biology to target serine hydrolases. The following case study on cholinesterases is the first comprehensive structure- reactivity exploration of the carbamoyl warhead, rather than one-target-oriented structure- activity study, with in-depth profiling of diverse halogen, chalcogen, and nitrogen-based leaving groups (nucleofuges) that can tune warhead reactiv...

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Literature Corpus work: 4bda21ab-bb04-522b-a05f-e2795c4c72be
DOI: 10.1101/2025.08.20.671340

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