Back to search

Article

Arp2/3 complex-dependent actin regulation protects the survival of tissue-resident mast cells

2024-02-25

Abstract excerpt

Actin network dynamics are pivotal in governing the motility and effector functions of immune cells. The Arp2/3 complex is a key regulator of actin filament branching, with mutations in its subunits being linked with human immunodeficiencies. While known for its role in phagocytosis and cell migration, our study uncovers a critical role of the Arp2/3 complex in safeguarding the tissue residency of mast cells (MCs)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
72330807-90e1-5172-9a72-07f1f31ef7ba
DOI
10.1101/2024.02.23.581763
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Arp2/3 complex-dependent actin regulation protects the survival of tissue-resident mast cellsDOI 10.1101/2024.02.23.581763
Arp2/3 Complex Is Required for Macrophage Integrin Functions but Is Dispensable for FcR Phagocytosis and In Vivo Motility.Semantic proximity
ARPC5 Isoforms and Their Regulation by Calcium-Calmodulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T CellsSemantic proximity
Emerging functions of cytoskeletal proteins in immune diseasesSemantic proximity
Branching out in different directions: Emerging cellular functions for the Arp2/3 complex and WASP-family actin nucleation factorsSemantic proximity
Branched actin networks mediate macrophage-dependent host microbiota homeostasisSemantic proximity
Deciphering actin remodelling in immune cells through the prism of actin-related inborn errors of immunity.Semantic proximity
Mast cells: Versatile regulators of inflammation, tissue remodeling, host defense and homeostasisSemantic proximity
Defective Neutrophil Transendothelial Migration and Lateral Motility in ARPC1B Deficiency Under Flow Conditions.Semantic proximity
The Arp2/3 Regulatory System and Its Deregulation in CancerSemantic proximity
Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype.Semantic proximity
The Actin Regulators Involved in the Function and Related Diseases of LymphocytesSemantic proximity
DOCK8 regulates a mechanosensitive actin redistribution that maintains immune cell cohesion and protects the nucleus during migrationSemantic proximity
Select a neighboring publication to make it the new centre.