Article

Phasing Diploid Genome Assembly Graphs with Single-Cell Strand Sequencing

2024-02-16

Abstract excerpt

Haplotype information is crucial for biomedical and population genetics research. However, current strategies to produce de-novo haplotype-resolved assemblies often require either difficult-to-acquire parental data or an intermediate haplotype-collapsed assembly. Here, we present Graphasing, a workflow which synthesizes the global phase signal of Strand-seq with assembly graph topology to produce chromosome-scale...

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Literature Corpus work: df71d959-323c-54fe-8266-fc98b3490a43
DOI: 10.1101/2024.02.15.580432

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