Article

Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform

2022-06-23

Abstract excerpt

<h4>ABSTRACT</h4> Secreted proteins, which include cytokines, hormones and growth factors, are extracellular ligands that control key signaling pathways mediating cell-cell communication within and between tissues and organs. Many drugs target secreted ligands and their cell-surface receptors. Still, there are hundreds of secreted human proteins that either have no identified receptors (“orphans”) and are likely...

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Literature Corpus work: 81d3c617-128e-5e80-a7c1-5fab82c169d8
DOI: 10.1101/2022.06.22.497261

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