Article
The Immunoglobulin Superfamily Receptome Defines Cancer-Relevant Networks Associated with Clinical Outcome.
Cell - 23 Jul 2020
Verschueren Erik, Husain Bushra, Yuen Kobe, Sun Yi, Paduchuri Sairupa, Senbabaoglu Yasin, Lehoux Isabelle, Arena Tia A, Wilson Blair, Lianoglou Steve, Bakalarski Corey, Franke Yvonne, Chan Pamela, Wong Athena W, Gonzalez Lino C, Mariathasan Sanjeev, Turley Shannon J, Lill Jennie R, Martinez-Martin Nadia
Abstract excerpt
Cell surface receptors and their interactions play a central role in physiological and pathological signaling. Despite its clinical relevance, the immunoglobulin superfamily (IgSF) remains uncharacterized and underrepresented in databases. Here, we present a systematic extracellular protein map, the IgSF interactome. Using a high-throughput technology to interrogate most single transmembrane receptors for binding...
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