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Using proteomics and single-cell sequencing to analyze the pathogenesis of recurrent implantation failure associated with uterine natural killer cells

13 Jun 2025

Abstract excerpt

PROBLEM: Recurrent implantation failure (RIF) affects about 10% of infertility patients and may involve mid-luteal phase endometrial natural killer (NK) cells. The pathogenesis of NK cells in RIF remains unclear. METHOD OF STUDY: Our study integrated proteomics data from endometrial tissues of six RIF patients and six controls, with single-cell sequencing insights. RESULTS: Our proteomics analysis identified 1366...

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PMID: 40514455
DOI: 10.1007/s00404-025-08074-8

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