Article

Progression of <i>ampC</i> amplification during de novo amoxicillin resistance development in <i>E. coli</i>

2024-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Beta-lactam antibiotics are the most applied antimicrobials in human and veterinarian health care. Hence, beta-lactam resistance is a major health problem. Gene amplification of AmpC beta-lactamase is a main contributor to de novo β-lactam resistance in E. coli . However, the time course of amplification and the accompanying DNA mutations are unclear. Here, we study the progression of ampC amp...

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Literature Corpus work: 81d05c1e-e87c-5ee1-82dc-191931a43736
DOI: 10.1101/2024.05.24.595737

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