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Article

Progression of ampC amplification during de novo amoxicillin resistance development in E. coli.

mBio - 5 Feb 2025

Nong Luyuan, Jonker Martijs, de Leeuw Wim, Wortel Meike T, Ter Kuile Benno

Abstract excerpt

Beta-lactam antibiotics are the most applied antimicrobials in human and veterinarian health care. Hence, beta-lactam resistance is a major health problem. Gene amplification of AmpC beta-lactamase is a main contributor to de novo β-lactam resistance in Escherichia coli. However, the time course of amplification and the accompanying DNA mutations are unclear. Here, we study the progression of ampC amplification...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39704543
DOI: 10.1128/mbio.02982-24
PMCID: PMC11796351

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