Article
Hitchhiking genes and boundaries of AmpC amplicons during amoxicillin resistance development in E. coli.
BMC microbiology - 17 Nov 2025
Nong Luyuan, Wang Xinyu, Koenders Belinda, de Leeuw Wim, Jonker Martijs, Brul Stanley, Kuile Benno Ter
Abstract excerpt
BACKGROUND: Duplication and amplification of the chromosomal beta-lactamase gene ampC is a main mechanism for amoxicillin resistance development in E. coli. When E. coli is exposed to step-wise increasing amoxicillin concentrations, a fragment carrying the ampC gene can be amplified to high levels, resulting in up to 500 fold increased transcription of ampC. The size of the amplicon varies between replicates and...
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