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Progressive sub-MIC Exposure of <i>Klebsiella pneumoniae</i> 43816 to Cephalothin Induces the Evolution of beta-lactam Resistance without Acquisition of beta-lactamase Genes

2021-11-19

Abstract excerpt

Bacterial exposure to antibiotic concentrations below the minimum inhibitory concentration (MIC) may result in a selection window allowing for the rapid evolution of resistance. These sub-MIC concentrations are commonly found in the greater environment. This study aimed to evaluate the adaptive genetic changes in Klebsiella pneumoniae 43816 after prolonged but increasing sub-MIC levels of the common antibiotic ce...

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Literature Corpus work
6037714a-079f-5738-b870-689b6dae7db3
DOI
10.1101/2021.11.19.469034
Open publication

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Progressive sub-MIC Exposure of <i>Klebsiella pneumoniae</i> 43816 to Cephalothin Induces the Evolution of beta-lactam Resistance without Acquisition of beta-lactamase GenesDOI 10.1101/2021.11.19.469034
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