Article

NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity

2019-01-10

Abstract excerpt

<h4>ABSTRACT</h4> In response to genotoxic stress, multiple kinase signalling cascades are activated, many of them directed towards the tumour suppressor p53 which coordinates the DNA damage response (DDR). Defects in DDR pathways lead to an accumulation of mutations that can promote tumorigenesis. Emerging evidence implicates multiple members of the NimA-related kinase (NEK) family (NEK1, NEK10 and NEK11) in the...

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Literature Corpus work: 81b9b9ac-043d-5bfc-a288-1122df5f1354
DOI: 10.1101/516971

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