Article

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of <i>DYRK1A</i>

2023-12-10

Abstract excerpt

<h4>Summary</h4> Chromothripsis, the process of catastrophic shattering and haphazard repair of chromosomes, is a common event in cancer. Whether chromothripsis might constitute an actionable molecular event amenable to therapeutic targeting remains an open question. We describe recurrent chromothripsis of chromosome 21 in a subset of patients in blast phase of a myeloproliferative neoplasm (BP-MPN), which alongs...

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Literature Corpus work: 4d1602a6-512a-5e96-a766-fcf28665651c
DOI: 10.1101/2023.12.08.570880

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