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Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin

1 Jul 2020

Abstract excerpt

DNA double-strand breaks (DSBs) trigger transient pausing of nearby transcription, an emerging ATM-dependent response that suppresses chromosomal instability. We screened a chemical library designed to target the human kinome for new activities that mediate gene silencing on DSB-flanking chromatin, and have uncovered the DYRK1B kinase as an early respondent to DNA damage. We showed that DYRK1B is swiftly and...

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PMID: 32611815
DOI: 10.1073/pnas.2002193117

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Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatinPMID 32611815Read ↗

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