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A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response

12 Sept 2014

Abstract excerpt

The Replication Stress Response (RSR) is a signaling network that recognizes challenges to DNA replication and coordinates diverse DNA repair and cell-cycle checkpoint pathways. Gemcitabine is a nucleoside analogue that causes cytotoxicity by inducing DNA replication blocks. Using a synthetic lethal screen of a RNAi library of nuclear enzymes to identify genes that when silenced cause gemcitabine sensitization or...

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PMID: 25217585
DOI: 10.1093/nar/gku840

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