Article
NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity.
Oncogene - 1 Jul 2020
Haider Nasir, Dutt Previn, van de Kooij Bert, Ho Jason, Palomero Luis, Pujana Miquel Angel, Yaffe Michael, Stambolic Vuk
Abstract excerpt
In response to genotoxic stress, multiple kinase signaling cascades are activated, many of them directed towards the tumor suppressor p53, which coordinates the DNA damage response (DDR). Defects in DDR pathways lead to an accumulation of mutations that can promote tumorigenesis. Emerging evidence implicates multiple members of the NimA-related kinase (NEK) family (NEK1, NEK10, and NEK11) in the DDR. Here, we...
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