Article

Integrated Epigenetic and Transcriptomic Profiling Reveals Dynamic Regulatory Networks Driving Retinoblastoma Pathogenesis

2023-05-12

Abstract excerpt

Retinoblastoma (RB), the most aggressive pediatric intraocular malignancy, urgently requires mechanistic insights to overcome limitations of current clinical interventions. Through integrated single-cell multi-omics analysis, we constructed a comprehensive epigenetic-transcriptomic atlas of photoreceptor subpopulations in RB. Pseudotemporal trajectory analysis revealed the differentiation cascade from retinal prog...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 80ea54ce-b35b-596e-94ef-141dc267b41b
DOI: 10.1101/2023.05.10.540147

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated Epigenetic and Transcriptomic Profiling Reveals Dynamic Regulatory Networks Driving Retinoblastoma PathogenesisDOI 10.1101/2023.05.10.540147Read

Spatial transcriptomic profiling of human retinoblastomaSemantic proximity Read

A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression.Semantic proximity Read

Retinoblastoma: A review of the molecular basis of tumor development and its clinical correlation in shaping future targeted treatment strategiesSemantic proximity Read

Single-cell characterization of malignant phenotypes and microenvironment alteration in retinoblastoma.Semantic proximity Read

Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progressionSemantic proximity Read

Single-cell transcriptome profiling reveals intratumoural heterogeneity and malignant progression in retinoblastomaSemantic proximity Read

Molecular Biological Research on the Pathogenic Mechanism of RetinoblastomaSemantic proximity Read

Etiology including epigenetic defects of retinoblastoma.Semantic proximity Read

Transcriptome analysis reveals molecularly distinct subtypes in retinoblastomaSemantic proximity Read

Dissecting the Transcriptional and Chromatin Accessibility Heterogeneity of Proliferating Cone Precursors in Human Retinoblastoma Tumors by Single Cell Sequencing—Opening Pathways to New Therapeutic Strategies?Semantic proximity Read

E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma.Semantic proximity Read

Longitudinal analysis of retinal cell state transitions in <i>RB1</i> -deficient retinal organoids reveals the nascent cone precursors are the earliest cell-origin of human retinoblastomaSemantic proximity Read