Article
Computing hematopoiesis plasticity in response to genetic mutations and environmental stimulations.
Life science alliance - 1 Feb 2025
Wen Yuchen, He Hang, Ma Yunxi, Bao Dengyi, Cai Lorie Chen, Wang Huaquan, Li Yanmei, Zhao Baobing, Cai Zhigang
Abstract excerpt
Cell plasticity (CP), describing a dynamic cell state, plays a crucial role in maintaining homeostasis during organ morphogenesis, regeneration, and trauma-to-repair biological process. Single-cell-omics datasets provide an unprecedented resource to empower CP analysis. Hematopoiesis offers fertile opportunities to develop quantitative methods for understanding CP. In this study, we generated high-quality...
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