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Article

A catalog of gene editing sites and genetic variations in editing sites in model organisms.

BMC genomics - 29 Nov 2024

Yang Weilong, Zhu Jian-Kang, Jin Wenfei

Abstract excerpt

BACKGROUND: CRISPR-Cas systems require a protospacer adjacent motif (PAM), which plays an essential role in self/non-self discrimination in their natural context, to cleave DNA for genome editing. Unfortunately, common genetic variation is distributed throughout genomes, which can block recognition of target sites by Cas proteins. However, little information is available about the distribution of editing sites in...

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Identifiers

PMID: 39614172
DOI: 10.1186/s12864-024-11073-9
PMCID: PMC11606270

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