Article
Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003
Keightley Peter D, Gaffney Daniel J
Abstract excerpt
Selection against deleterious mutations imposes a mutation load on populations because individuals die or fail to reproduce. In vertebrates, estimates of genomic rates of deleterious mutations in protein-coding genes imply the existence of a substantial mutation load, but many functionally important regions of the genome are thought to reside in noncoding DNA, and the contribution of noncoding DNA to the mutation...
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