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Article

Roquin-dependent gene regulation in immune-mediated diseases and future therapies

16 Dec 2022

Abstract excerpt

The RNA-binding proteins Roquin-1/2 and Regnase-1 exert essential regulation by controlling pro-inflammatory mRNA expression to prevent autoimmune disease. More recently, inhibition of this post-transcriptional gene regulatory program has been demonstrated to enable enhanced anti-tumor responses by tumor antigen-specific CD8+ T cells. In this review, we describe the functions of these RNA-binding proteins and the...

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PMID: 36525589
DOI: 10.1093/intimm/dxac059

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