Article

Development of an engineered human enzyme for anti-vasculature immunotherapy

2011-01-01

Abstract excerpt

The tumour vasculature is an attractive target for cancer therapy because tumour growth and spread depend on these structures for oxygen and nutrient supply. Anti-vasculature therapy aims to cause rapid and selective shutdown of the established tumour vasculature, leading to secondary tumour cell death. In this study, we propose to employ an Antibody Guided Enzyme Nitrile Therapy (AGENT) approach to selectively ta...

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Identifiers and source

Literature Corpus work: 8115d9f5-512c-5845-a533-eb0fad927508
DOI: 10.25560/7120

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